Abnormality of phospholipids in red cells of patients with paroxysmal nocturnal haemoglobinuria.

Electron microscope study of PNH red cells and AET-treated normal red cells (PNH-like cells).

The morphology of red cells damaged by 2-aminoethylisothiouronium bromide (AET) has been compared to that of PNH cells by transmission and scanning electron microscopy. The main features of the effect of AET as demonstrated by the scanning electron microscope were spherical and deformed cells, with surface craters and relatively large pits. The transmission electron microscope revealed loss of ...

Paroxysmal nocturnal haemoglobinuria with renal, infective and immunological abnormalities.

Introduction Paroxysmal nocturnal haemoglobinuria (PNH) is a rare disease characterized by a membrane abnormality of red cells leading to episodic haemolysis. It has only occasionally been observed in the elderly (Sirchia and Lewis, 1975). The rarity of the disease, the insidious development of symptoms and variety of presentations mean that diagnosis may be incorrect or delayed (Polli et al., ...

Paroxysmal nocturnal haemoglobinuria-like defect in red cells in chronic lymphatic leukaemia.

Severe haemolysis and renal failure in a patient with paroxysmal nocturnal haemoglobinuria.

Transfusion of about 60 ml of ABO incompatible plasma in 4 units of pooled platelets precipitated severe haemolysis, unmasking the emergence of paroxysmal nocturnal haemoglobinuria (PNH), in a patient with aplastic anaemia. In vitro tests showed that her red cells were lysed by both ABO compatible and incompatible plasma from normal donors. The behaviour of this case and the in vitro results su...

Haemoglobinuria And Portal Venous Thrombosis In A Young Male.

Paroxysmal nocturnal haemoglobinuria is a non-malignant stem cell disorder due to acquired somatic mutations in cell surface anchored proteins CD55 and CD59. Both have a compliment inhibitory role and their deficiency leads to intravascular haemolysis. This paper reports a challenging case of a 25 years old male who presented with generalized weakness, exertional dyspnoea and episodic early mor...